Cell Pathways other research news

At the meeting of the American Gastroenterological Association and the American Association for the Study of Liver Diseases in San Francisco, company researchers reported that there is a pathway separate from p53 that can induce apoptosis in either dividing or resting cancer cells.

Sulindac is a non-steroidal anti-inflammatory drug. Both its sulfide metabolite and FGN-1, a sulfone derivative, appear to induce apoptosis in tumor cells by a different pathway than p53, the researchers said. They showed that both sulindac sulfide and FGN-1 increased apoptosis in a HT-29 colon tumor cell line without altering the cells' expression of p53. Both also induced apoptosis in Saos-2 cells, which lack a functional p53 protein. ...