Oncor, Yale University School of Medicine other research news

Researchers found that three triplex forming oligonucleotides (AG10, AG20 and AG30) stimulated DNA repair synthesis and mutations in human cell extracts, according to an article published in Science.

Triplex-mediated transcription inhibition may induce mutations when transcription stalls at natural pause sites, leading to gratuitous repair and repetitive generation of repair patches. In theory, this "hyperreactivity" has the potential to introduce mutations into DNA. The findings raise the question whether naturally occurring triple helixes are a source of genetic instabilty. ...