Diethylnorspermine: SUNP and Warner-Lambert have reached the maximum tolerated dose in Phase I trials

The compound is a synthetic polyamine analog that is similar in structure to naturally occurring polyamines, which are necessary for cell proliferation and protein synthesis. Cancer cells contain higher concentrations of polyamines than normal cells.

More than 55 patients have received DENSPM, with additional trials being conducted to determine the MTD for the one dose/day level, and to confirm that the drug can be given safely three times per day. ...