Alexion preclinical data

ALXN's murine MAb inhibited a lupus-like condition in mice, with onset of the disease delayed and survival prolonged, according to a report in the Proceedings of the National Academy of Sciences.

The lupus-like syndrome, which culminates in death from kidney damage by 12 months of age, arises spontaneously in the females of certain mice. In the experiments, animals were treated with the MAb at increasing frequency as they aged. Therapy for six months prolonged survival from less than 5 percent in controls to >80 percent in the treated mice. Histology showed decreased kidney damage as well. ...