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The South San Francisco company published in Science the details of action of signal transducers that carry the intracellular messages sent by TNF binding at the cell surface.

Various TRAF proteins carry the signals, which activate transcription factor NF-kB. The TRAF2 protein turns out to be a common mediator of signaling by the TNF-R2 receptor and the CD40 receptor. CD40 is also a member of the TNF receptor superfamily. ...