Apollon, Theratechnologies other research news

Two articles from university researchers in Virology lend additional support to the importance of the role of the Vpr gene in the replication of HIV.

Researchers from the Aaron Diamond AIDS Research Center and collaborators showed that Vpr arrests the cell cycle in the second gap (G2) phase, by preventing activation of the p34cdc2/cyclin B complex. Activation of that complex is required for cells to enter into the M (mitosis) phase of the cell cycle. Vpr might, by preventing p34cdc2 activation, delay or prevent apoptosis of infected cells in vivo. This, they concluded, would increase the amount of virus each infected cell produced (see BioCentury, Oct. 2). ...