University of Texas other research news

Researchers at the university’s Health Science Center reported on the abnormal cellular location of a possible marker of breast cancer. Their findings suggest that BRCA1 abnormalities may be involved in the pathogenesis of many breast cancers, sporadic as well as familial.

As published in Science, the protein coded by the BRCA1 gene was found in the nucleus in normal cells, and in normal breast duct cells, and in 18 of 20 tumor cells from tissues other than breast or ovary. In 16 of 17 breast or ovary cancer lines, and in all of 17 samples of malignant effusions, the marker was in the cytoplasm. ...