ARTICLE | Clinical News

Recombinant human bactericidal/permeability-increasing protein data

May 2, 1994 7:00 AM UTC

IPI published mouse data in Critical Care Medicine showing that the binding affinity of BPI for endotoxin is greater than the binding affinities of Centocor Inc.'s HA-1A monoclonal antibody and Xoma Corp.'s E5 MAb.

In addition, administration of BPI gave greater than 90 percent protection against an LD60 (60 percent lethal) dose of endotoxin in mice, while treatment with HA-1A or E5 didn't improve survival. ...