GS 393 data

GILD (Foster City, Calif.) published data from monkeys showing that pretreatment with the agent 48 hours before inoculation with SIV protected 83 percent of the macaques given 20 mg/kg/day, and only 50 percent of those given 10 mg/kg/day.

Only two of 12 animals given the higher dose showed infection, while three of the six given the lower dose were virus-positive. Measures used included SIV in blood, SIV DNA in monocytes, and SIV antibodies. Dosing continued for both groups for 28 days after the SIV inoculation. ...