Ampakine benzamide compounds that cross the blood-brain barrier and potentiate glutamate at the AMPA receptor data

CORX (Irvine, Calif.) published animal data showing the memory-boosting action of one of a new class of compounds, called ampakines, as demonstrated in three memory-based tasks performed by rats.

The agents enhance the flow of impulses at the AMPA glutamate receptor in the brain. In the Proceedings of the National Academy of Sciences, researchers associated with CORX showed that one of the benzamide compounds enhanced the excitatory signals generated in the hippocampus, a brain structure associated with memory, in tissue slices and in live rats. ...