Children's Hospital Medical Center, Cincinnati other research news

University researchers published in Science that the human gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), targeted to the intestine, enabled mice to survive the genetic defect that usually kills them in infancy. Mice bearing mutated CFTR die of intestinal blockage in the first month of life.

The human gene construct was microinjected into fertilized eggs to produce transgenic mice, which were shown to express the human gene in their intestinal tract but with little or no expression in the lungs or nasal passages. ...