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Amylin other research news

April 25, 1994 7:00 AM UTC

Harvard scientists conducting independent research demonstrated that the insoluble, fibrillar form of human amylin is toxic to pancreatic islet cells. The toxic effect, which appears to cause induction of programmed cell death or apoptosis, was concentration-dependent and occurred only at high levels, according to a report in Nature.

The toxic effect of amylin was demonstrated in rat islet cell cultures and in pancreatic tissue taken from a human patient, indicating that amylin fibril formation in the pancreas may cause islet cell dysfunction in Type II diabetes. ...