Microemulsion drug delivery system for calcitonin data

AFBI completed a proof-of-concept trial in Scotland for its microemulsion drug delivery system. The proprietary, suppository form of calcitonin was given to six healthy volunteers. The patients also received, at a different time, an intramuscular injection of calcitonin to establish a baseline for bioavailability measures. Blood samples taken after each administration showed a lowering of serum calcium and phosphate levels, commensurate with the blood levels of drug attained with the injections, said executive vice president Wayne Weisman. A relative bioavailability of 5 percent was achieved, as compared to 4 percent commonly attained by nasal forms of calcitonin. ...