Magainin preclinical data

In a mouse model of androgen-dependent prostate cancer, squalamine maintained prostate specific antigen (PSA) at undetectable levels for the duration of the 12-week study and gave complete disappearance of tumors, while tumors in control mice grew.

Separately, in a mouse xenograft model of lung tumors, the combination of squalamine and cisplatin gave 85.5 percent tumor growth inhibition (TGI) compared to 70.3 percent for cisplatin alone after one month (p=0.048). Squalamine alone gave a TGI of 20.6 percent. The combination of squalamine, carboplatin and paclitaxel gave a mean tumor shrinkage of 54.8 percent and a TGI of 95.7 percent compared to no tumor shrinkage and a TGI of 55.9 percent for carboplatin and paclitaxel alone (p=0.001). ...