BioCentury
ARTICLE | Clinical News

Fujisawa Institute of Neuroscience preclinical data

September 26, 1994 7:00 AM UTC

Researchers published evidence in a rat model of stroke that the immune suppressant agent can reduce the degree of cortical injury after blockade of the middle cerebral artery.

As presented in Nature, the drug spared cortex at doses similar to those that suppress the immune system. Cortical damage was reduced by about 60 percent, an efficacy equivalent to that of the neuroprotective NMDA antagonist MK801. The agent worked even when given an hour after the blockage was induced. ...