CytoTherapeutics preclinical data

The Providence, R.I., company and collaborators published data from aged monkeys showing that the nerve growth factor in CTII's CRIB device can prevent the degeneration caused by cutting a bundle of nerves within the brain.

Severing the fornix, a model of Alzheimer's, causes degeneration of cholinergic neurons in the basal forebrain that is reversed by NGF. In the three monkeys who received CRIB implants after the cut, there was only a 36 percent maximal loss of a cholinergic enzyme and a 22 percent maximal loss of receptor for NGF. ...