Triplex Pharmaceutical Corp. other research news

The Woodlands, Texas, company published cell culture results on a series of oligonucleotide compounds that appear to interrupt the life cycle of HIV, independently of antisense or other code-blocking actions. Instead, the GTOs seem to interfere with the various enzymes that direct viral infection and replication.

As reported in the Journal of Acquired Immune Deficiency Syndromes, GTOs may bind to both gp120 and CD4, thus blocking viral entry. They also seem to inhibit reverse transcriptase and integrase enzyme activities. ...