MAb 3E10 murine idiotype antibody data

The Los Angeles company announced preliminary evidence that the intended anti-idiotype reaction is being generated by the therapeutic vaccine, which uses an antibody cloned from MRL/1pr mice that model the human disease.

Six patients who failed conventional therapy have completed the injection portion of the Phase I trial. Five received the antibody; of these, one showed HAMA (human anti-mouse-antibody) response by the fourth injection. The other four showed a weaker anti-idiotype response. ...