DNA-liposome encoding HLA-B7 major histocompatibility complex protein data

Scientists working with the company reported safety and efficacy in five patients with advanced, incurable melanoma in the Proceedings of the National Academy of Sciences.

The direct injection of the DNA construct, encased in liposomes, caused tumor regression in one of the five patients, and was not associated with any ill effects in any of the patients. Direct injection avoids the safety questions raised over genes delivered by viral vectors, the scientists noted. ...