Aeolus preclinical data

In mice exposed to total body irradiation of 7 Gy, AEOL 10150 plus Neupogen filgrastim significantly reduced the percentage of damaged lung tissue to 21% at 65 days post-exposure vs. 42% for Neupogen alone. At both 65 and 135 days post-exposure, AEOL 10150 also reduced fibrosis and alveolar and perivascular inflammation that resulted from irradiation with 7 Gy and treatment with Neupogen alone. AEOL 10150 is being developed under the FDA Animal Efficacy Rule for the pulmonary injury indication. FDA's Animal Rule allows marketing approval to be granted based on efficacy in relevant animal models and an acceptable safety risk profile in humans. ...