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488 items
5:55 PM, Oct 18, 2018  |  BC Innovations | Translation in Brief

Sorting out exosomes

A team of Japanese researchers have identified UBL3 as a new therapeutic target for cancers and neurodegenerative diseases that spread via the exosome-based intercellular communication system. The ubiquitin system sorts proteins for cellular export via...
1:38 PM, Oct 17, 2018  |  BC Innovations | Translation in Brief

Ciclopirox the chaperone

Atlas Molecular Pharma S.L. plans to repurpose antifungal drug ciclopirox to treat congenital erythropoietic porphyria after discovering it allosterically stabilizes an enzyme driving the disease. Atlas and colleagues from Center for Cooperative Research in Biosciences...
3:23 PM, Oct 11, 2018  |  BC Innovations | Translation in Brief

Cancer antigens from RNA edits

A team from Immatics Biotechnologies GmbH and University of Texas MD Anderson Cancer Center has shown that cancer antigens generated via post-transcriptional RNA editing could further broaden the target space for immunotherapies. The study, published in...
3:19 PM, Oct 11, 2018  |  BC Innovations | Translation in Brief

Public funding highlights: 3Q18

Public funding highlights: 3Q18 Selected developments and initiatives in 3Q18 from major sources of public funding including NIH, the U.K.’s Medical Research Council (MRC), the Innovative Medicines Initiative (IMI), the Canadian Institutes of Health Research (CIHR)...
12:15 PM, Oct 11, 2018  |  BC Innovations | Translation in Brief

Profiling long non-coding RNA function

A team at the University of North Carolina at Chapel Hill has developed a computational algorithm to predict the functions of long non-coding RNAs, an advance that could eventually lead to the development of therapeutics...
8:31 AM, Oct 04, 2018  |  BC Innovations | Translation in Brief

Risk Management Machinery

A Stanford University team has developed an AI platform that combines genomic and electronic health record data to help manage the risk of disease and identify new therapeutic targets. The group plans to out-license the...
4:17 PM, Oct 03, 2018  |  BC Innovations | Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

New Therapeutic Targets and Biomarkers: September 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in September. Therapeutic targets are defined as any protein, gene or other molecule that...
1:35 PM, Oct 03, 2018  |  BC Innovations | Translation in Brief

Salivary clues in autism

Salivary miRNA and microbial RNA could be used as biomarkers to diagnose autism spectrum disorder, according to research from Quadrant Biosciences Inc., State University of New York Upstate Medical University and Pennsylvania State University. The...
1:45 PM, Sep 27, 2018  |  BC Innovations | Translation in Brief

Twice as splice

Abivax S.A. (Euronext:ABVX) has positioned its anti-HIV therapy ABX464 to take on inflammatory diseases after discovering the small molecule triggers RNA splicing that both halts HIV viral replication and boosts anti-inflammatory responses in HIV and...
3:39 PM, Sep 26, 2018  |  BC Innovations | Translation in Brief

PK prediction help

In an August Drug Metabolism and Disposition study, a team from Alkermes plc (NASDAQ:ALKS), Pfizer Inc. (NYSE:PFE) and Biogen Inc. (NASDAQ:BIIB) assembled PK and physicochemical properties for over a thousand IV-delivered small molecules into a...

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