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12:00 AM, Dec 04, 2014  |  BC Innovations | Cover Story

GPCRs' grand plans

to expand tenfold the number of known 3D structures of the highly druggable class of GPCRs …
Pharmaceutical Co. Ltd. and Sanofi have teamed up with three academic organizations to create the GPCR
Consortium -a precompetitive alliance to build an open-source repository of GPCR structures. The consortium could fill …
12:00 AM, Aug 22, 2013  |  BC Innovations | Cover Story

Deep pockets

The B class of GPCRs is brimming with therapeutic targets, but thus far, development of small …
members of the family could change that and open up new therapeutic real estate. 1,2 GPCRs …
drugs. 3 Despite years of research and numerous approvals, predicting the relationship between ligands and GPCRs …
12:00 AM, Jan 24, 2013  |  BC Innovations | Cover Story

In silico drug design

build Bayesian models of ligand activity across 784 human protein targets, including G protein-coupled receptors (GPCRs …
way that you couldn't in your head. For example, it's been very difficult to design GPCR
been designed quasi-randomly based on hope and luck," said Jon Mason, senior research fellow at GPCR
12:00 AM, Nov 10, 2011  |  BC Innovations | Cover Story

Arrestin psychosis

The team was guided by previous work in multiple labs that showed G protein-coupled receptors (GPCRs …
first described the role the b-arrestin pathway plays as a regulator and signaling mediator of GPCRs …
He also is a cofounder of Trevena Inc. , which is focused on developing GPCR ligands …