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12:00 AM, Aug 27, 2015  |  BC Innovations | Distillery Techniques

Techniques: Atomic force microscopy (AFM) for measuring GPCR-ligand binding in lipid membranes

and screens TECHNOLOGY: Binding assays An AFM-based method could measure binding affinities between ligands and GPCRs …
in lipid membranes. The method involves attaching a GPCR ligand to the tip of an oscillating …
cantilever moving toward and away from a synthetic bilayer containing the GPCR, and using AFM to …
12:00 AM, Jun 04, 2015  |  BC Innovations | Distillery Techniques

Techniques: Peptide agonists of adhesion G protein-coupled receptors (GPCRs)

Drug platforms TECHNOLOGY: Peptides Peptides derived from the extracellular stalk region of adhesion GPCRs could agonize …
the corresponding full receptors in adhesion GPCR-related diseases. In adhesion GPCRs, the extracellular stalk region is …
with no treatment. Next steps could include designing stalk peptides that activate clinically relevant adhesion GPCRs …
12:00 AM, Sep 18, 2014  |  BC Innovations | Distillery Techniques

Technology: Assays & screens

and contact information Assays & screens Programmable ligand display system to identify multivalent binders to GPCRs …
A programmable ligand-display system could be useful for identifying high-affinity compounds that bind GPCR targets. The …
nucleic acids (L-PNAs) and complementary DNAs to generate libraries of multivalent scaffolds against a particular GPCR
12:00 AM, Oct 17, 2013  |  BC Innovations | Distillery Techniques

Technology: Drug platforms

and contact information Drug platforms Stabilizing, camelid-derived nanobodies to facilitate generation of crystal structures of GPCRs …
Stabilizing, camelid-derived antibody fragments called nanobodies could be useful for generating the crystal structure of GPCRs …
similar for all ligands. Next steps could include applying the approach to other therapeutically relevant GPCR
12:00 AM, Aug 29, 2013  |  BC Innovations | Distillery Techniques

Technology: Drug platforms

receptor (GCGR) A crystal structure of GCGR could help drug discovery efforts targeting class B GPCRs …
of helix I that may be involved in glucagon (GCG) binding. Compared with class A GPCR
Next steps could include building models of interactions between peptide ligands and other class B GPCRs …
12:00 AM, Aug 22, 2013  |  BC Innovations | Distillery Techniques

Technology: Drug platforms

structure of an antagonist-bound CRHR1 could help inform the development of compounds targeting class B GPCRs …
is in a deep hydrophobic pocket ~13-23 Å away from ligands that bind class A GPCRs …
Next steps include combining these and other structural data to build a model of another GPCR
12:00 AM, Jan 17, 2013  |  BC Innovations | Distillery Techniques

Technology: Computational models

Licensing status Publication and contact information Computational models Computational algorithm for designing G protein-coupled receptor (GPCR
ligands against a predefined set of targets A computational algorithm could be used to design GPCR
12:00 AM, Feb 10, 2011  |  BC Innovations | Distillery Techniques

Technology: Drug platforms

Summary Licensing status Publication and contact information Drug platforms Nanobody stabilization of G protein-coupled receptors (GPCRs …
for activated structure determination Nanobodies could help determine the structures of activated GPCRs to guide the …
of the selected nanobody and the complex enabled determination of the structure of the activated GPCR
12:00 AM, Apr 10, 2008  |  BC Innovations | Distillery Techniques

This Week in Techniques

This week in techniques Approach Summary Licensing status Publication and contact information Virtual screening for GPCR
antagonists A four-step virtual screening method could be superior to current GPCR virtual screens for identifying …
therapeutic leads to treat multiple diseases. Unlike previous GPCR screens, the new screen includes conformational flexibility …