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12:05 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes Patient sample and mouse studies suggest inhibiting ANGPTL4 could help treat insulin resistance. In …
non-diabetic individuals, a loss-of-function mutation in ANGPTL4 was associated with low levels of fasting blood glucose …
and high insulin sensitivity. In a high-fat diet-induced mouse model of insulin resistance, systemic ANGPTL4 knockout …
3:22 PM, Jan 26, 2017  |  BC Innovations | Strategy

Deep roots

In a New England Journal of Medicine study published last March, the partners showed inactivating ANGPTL4
from the Geisinger cohort were associated with decreased triglyceride levels and risk of CAD. An anti-ANGPTL4
Euronext:SAN; NYSE:SNY), Paris, France Vanderbilt University, Nashville, Tenn. Targets and Compounds  ANGPTL3 - Angiopoietin-like 3 ANGPTL4
6:18 AM, Dec 22, 2016  |  BC Innovations | Targets & Mechanisms

Opportunity Knocks

binding protein p300 (EP300; p300) 10 Cancer ADAM metallopeptidase domain 10 (ADAM10) 6 Cancer; neurology Angiopoietin-like 4
ANGPTL4) 6 Cancer; ophthalmic disease Annexin A1 (ANXA1) 6 Cancer Caspase-3 (CASP3; CPP32) 6 Cancer; neurology …
12:00 AM, Jun 18, 2015  |  BC Innovations | Distillery Therapeutics

Therapeutics: Angiopoietin-like 4 (ANGPTL4)

Ophthalmic disease INDICATION: Diabetic retinopathy In vitro studies suggest inhibiting ANGPTL4 could help treat proliferative diabetic …
retinopathy (PDR). ANGPTL4 levels were higher in aqueous fluid from the eyes of PDR patients than …
microvascular endothelial cell-based angiogenesis assay, pretreatment of aqueous fluid samples from PDR patients with an anti-ANGPTL4
12:00 AM, Jan 30, 2014  |  BC Innovations | Distillery Therapeutics

Indication: Renal disease

in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Renal disease Renal disease Angiopoietin-like 4
ANGPTL4); integrin aVb5 Rat studies suggest ANGPTL4 variants that selectively bind to integrin aVb5 could help …
have not been functionally linked. In rat models of a precursor phase of nephrotic syndrome, Angptl4
12:00 AM, Sep 19, 2013  |  BC Innovations | Distillery Therapeutics

Indication: Ophthalmic disease

Summary Licensing status Publication and contact information Ophthalmic disease Diabetic retinopathy; diabetic macular edema (DME) Angiopoietin-like 4
ANGPTL4) Mouse and cell culture studies suggest inhibiting ANGPTL4 could help treat ischemic retinopathies such as …
oxygen-induced retinopathy, hypoxic retinal Müller cells were shown to promote vascular permeability by upregulation of Angptl4
12:00 AM, Feb 11, 2013  |  BioCentury | Emerging Company Profile

GeneCentric: Cancer sign-off

to an anti-angiogenesis drug, she said. The gene signature, also licensed from UNC, includes VEGF, angiopoietin-like 4
ANGPTL4) , adrenomedullin (ADM; AM) and solute carrier family 16 member 3 (SLC16A3) . Perou was …
12:00 AM, Dec 03, 2012  |  BioCentury | Emerging Company Profile

Lipigon: LPL protectorate

activity to about 60,000 ester bonds per minute. By contrast, in disease states, inhibitors including angiopoietin-like 4
ANGPTL4) and apolipoprotein C-III ( APOCIII ; APOC3 ) become overly active and cleave LPL into …
12:00 AM, Mar 31, 2011  |  BC Innovations | Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Angiopoietin-like 4
ANGPTL4) In vitro and mouse studies suggest that inhibiting ANGPTL4 could help treat cancer. In human …
tumor tissue arrays, ANGPTL4 expression was greater than that in corresponding normal tissues. In mice with …
12:00 AM, Aug 19, 2010  |  BC Innovations | Distillery Therapeutics

Indication: Cancer

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Kaposi's sarcoma (KS) Angiopoietin-like 4 (ANGPTL4
In vitro and mouse studies suggest that inhibiting ANGPTL4 could help treat KS. In experimental and …
patient KS lesions, ANGPTL4 levels were greater within the lesions than outside them. In a KS …

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