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6:57 AM, Mar 08, 2017  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Zebrafish studies suggest inhibiting TGFβ1 or LFA-1 could help treat metastatic breast cancer …
tissue. In two xenograft zebrafish models of metastatic breast cancer, antibodies against human TGFβ1 or LFA-1
metastasis compared with an isotype-matched control antibody. Next steps could include testing the anti-TGFβ1 and anti-LFA-1
12:00 AM, Aug 13, 2015  |  BC Innovations | Distillery Therapeutics

Therapeutics: LFA-1 (CD11a-CD18)

disease (AD) Mouse studies suggest temporary depletion of neutrophils or inhibition of the neutrophil-trafficking protein LFA-1
In a transgenic mouse model of AD, systemic depletion of neutrophils or treatment with an anti-LFA-1
respectively. Next steps include investigating other undisclosed leukocyte proteins that contribute to AD pathology. TARGET/MARKER/PATHWAY: LFA-1
12:00 AM, Nov 03, 2011  |  BC Innovations | Distillery Therapeutics

Indication: Autoimmune disease

status Publication and contact information Autoimmune disease Multiple sclerosis (MS) Integrin aL (CD11A); integrin b2 (LFA-1
12:00 AM, Nov 03, 2011  |  BC Innovations | Distillery Therapeutics

Indication: Autoimmune disease

Anderson Cancer Center, Houston, Texas e-mail: cdong@mdanderson.org Multiple sclerosis (MS) Integrin aL (CD11A); integrin b2 (LFA-1
12:00 AM, May 05, 2011  |  BC Innovations | Distillery Therapeutics

Indication: Inflammation

Licensing status Publication and contact information Inflammation Inflammation Growth differentiation factor 15 (GDF15); integrin b2 (LFA-1
12:00 AM, Dec 18, 2008  |  BC Innovations | Distillery Therapeutics

This week in therapeutics

Inflammation Inflammation EGF-like repeats and discoidin I-like domains 3 (EDIL3; DEL1); lymphocyte function-associated antigen 1 (CD11a-CD18
LFA-1) Studies in mice suggest that increasing DEL1 expression may be useful for decreasing inflammation. In …
and to test the compound in mouse models of inflammation. At least five companies have LFA-1
12:00 AM, Feb 21, 2008  |  BC Innovations | Distillery Therapeutics

This Week in Therapeutics

to an activated form of a4b7 on CD4+ T cells and activated lymphocyte function-associated antigen-1 (LFA-1
LFA-1 activation plays a role in the spread of HIV infection via direct cell-to-cell contact between …