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11:13 AM, Mar 07, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Solid tumors In vitro and cell culture studies identified Hsp90B1 inhibitors that could help treat …
synthesis, in vitro binding and cell-based assays of resorcinol analogs yielded a compound that inhibited Hsp90B1
compound in animal models of solid tumors. TARGET/MARKER/PATHWAY: Heat shock 90 kDa protein β 1 (Hsp90B1
12:00 AM, Feb 04, 2016  |  BC Innovations | Distillery Therapeutics

Therapeutics: Proprotein convertase subtilisin/kexin type 9 (PCSK9); heat shock 90 kDa protein β 1 (Hsp90B1; GP96; GRP94)

Endocrine/metabolic disease INDICATION: Hypercholesterolemia Cell culture studies suggest a peptide derived from the PCSK9 chaperone Hsp90B1
could help treat hypercholesterolemia. The peptide comprised the Hsp90B1 C-terminal and PCSK9-binding domains but lacked its …
In a normal human cell line, the peptide bound PCSK9 with greater potency than full-length Hsp90B1
12:00 AM, May 01, 2014  |  BC Innovations | Distillery Therapeutics

Indication: Cancer

vaccines adjuvanted with allogeneic cancer cells that continually secrete heat shock 90 kDa protein b1 (Hsp90B1
GP96; GRP94). The company's most advanced ImPACT cancer vaccine is HS-110, which is in Phase II …
12:00 AM, Oct 03, 2013  |  BC Innovations | Distillery Therapeutics

Indication: Cancer

contact information Cancer Cancer Heat shock protein 90 (Hsp90); heat shock 90 kDa protein b1 (Hsp90B1
GP96; GRP94) In vitro studies identified a purine-based specific inhibitor of the Hsp90 family protein GRP94
upregulation of other heat shock proteins. In a human breast cancer cell line, inhibition of GRP94