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TRV027 (formerly TRV120027)

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Company Trevena Inc.
DescriptionDual-acting ligand that inhibits angiotensin-mediated G-protein signaling and stimulates beta arrestin signaling via the angiotensin II type 1 (AT1) receptor (AGTR1)
Molecular Target Angiotensin II type 1 (AT1) receptor (AGTR1)
Mechanism of ActionAngiotensin II type 1 (AT1) receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II
Standard IndicationHeart failure
Indication DetailsTreat acute decompensated heart failure (ADHF); Treat acute heart failure (AHF); Treat chronic heart failure; Treat heart failure
Regulatory Designation


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