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Targets & Mechanisms: Joint attack

Targeting overactive fibroblasts could prevent joint damage in RA

By Stephen Parmley, Senior Writer

A newly discovered pathway that causes joint erosion in rheumatoid arthritis could lead to a new class of therapies that act locally in cells of the synovial lining and avoid the drawbacks of immunosuppressants.

The pathway was identified by a group at the La Jolla Institute for Allergy & Immunology, which found that activation of a receptor phosphatase on synovial fibroblasts reduced the cells' pathological activity.

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  • THE DISTILLERY brings you this week's most essential scientific findings in therapeutics, distilled by Innovations editors from a weekly review of more than 400 papers in 41 of the highest-impact journals in the fields of biotechnology, the life sciences and chemistry. The Distillery goes beyond the abstracts to explain the commercial relevance of featured research, including licensing status and companies working in the field, where applicable.

    This week in therapeutics includes important research findings on targets and compounds, grouped first by disease class and then alphabetically by indication.

    This week in techniques includes findings about research tools, disease models and manufacturing processes that have the potential to enable or improve all stages of drug discovery and development.

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