Two new techniques for exploiting soil bacteria to find antibiotics have uncovered compound classes and targets that could impact the field even more than the pair of antimicrobials discovered.
TARGETS & MECHANISMS
A single receptor found to mediate allergic drug reactions could lead to an antidote and allow compounds to be screened out early during drug discovery.
A new strategy that homes in on major nodes of cancer pathways offers a faster and more informative way to find mutations that cause drug resistance than the standard needle-in-haystack approach.
Public funding saw none of the exuberance of the private sector in 2014, but NIH wants to use big data initiatives to stretch its use of funds
TRANSLATION IN BRIEF
Two academic deals in immune modulation and cancer for Boehringer Ingelheim; predicting responders in AML; designer small molecules that act like antibodies.
THE DISTILLERY brings you this week's most essential scientific findings in therapeutics, distilled by Innovations editors from a weekly review of more than 400 papers in 41 of the highest-impact journals in the fields of biotechnology, the life sciences and chemistry. The Distillery goes beyond the abstracts to explain the commercial relevance of featured research, including licensing status and companies working in the field, where applicable.
This week in therapeutics includes important research findings on targets and compounds, grouped first by disease class and then alphabetically by indication.
This week in techniques includes findings about research tools, disease models and manufacturing processes that have the potential to enable or improve all stages of drug discovery and development.