A synthetic, universal heparin reversal agent could provide a lower-risk option for preventing bleeding during surgery than protamine, the standard of care, but finding industry partners could be the challenge.
TARGETS & MECHANISMS
Chinese researchers have found that the generic alpha-blocker terazosin prevents apoptosis and want to pursue it for stroke, but they will need to navigate a landscape of difficult preclinical models.
A Duke team has found a new role for PIEZO calcium channels in cartilage damage, suggesting channel inhibitors could be developed for joint injury or osteoarthritis.
Micreos and ContraFect are separately developing phage lysins, which are not prone to bacterial resistance, as complements to antibiotics.
miR-24 to prevent abdominal aortic aneurysms; demethyleneberberine to treat alcoholic liver disease; distal airway stem cell transplants to regenerate injured lung tissue; and more...
Controlling Plasmodium falciparum gene expression to identify new malaria targets; using gp130-expressing mice as models of MM; diagnosing familial cold autoinflammatory syndrome with an NLRC4 mutation; and more...