Skip to main content
Feature Story

Paperback diagnostics

By Lauren Martz, Staff Writer

A paper-based diagnostic platform invented by Harvard University bioengineers could provide a cheap, portable and easy-to-use system for detecting pathogens in hospitals or developing-world settings.1 The technology uses embedded gene expression systems and can detect isolated mRNA biomarkers, but it will need to detect sequences in complex biological samples before it can be put into practice beyond the lab.

The diagnostic was created by a team led by James Collins at the Wyss Institute for Biologically Inspired Engineering at Harvard University who wanted to find real-world applications for synthetic gene networks. According to Collins, those systems have not gained traction yet in treatment settings because of concerns over safety and the complex apparatus involved.

Full Article

Sunshine Act


    Tapping TOPK

    OncoTherapy Science has a potent TOPK inhibitor in a liposomal formulation that avoids the toxicity of other cytokinesis-targeted compounds.


    Mixing it up at Karolinska

    Karolinska's new deputy vice chancellor, Alexander von Gabain, has plans to break down silos and breed new mindsets to maximize the institute’s translational potential.


    Paperback diagnostics

    A paper-based diagnostic using RNA switches could provide an easily distributed, rapid test for infectious diseases in point-of-care settings.

  • HemoShear's human touch

    HemoShear's in vitro tumor model shows a new application for its tissue modeling technology and could open it to business from oncology companies.


    This Week in Therapeutics

    Overcoming oncogenic KRAS-driven chemotherapy resistance by blocking NRF2 signaling; trifunctional arylpiperazine analogs as antipsychotic agents; inhibiting TRPM2 or RAC1 to treat ischemic kidney injury; and more...


    This Week in Techniques

    Lysyl oxidase to enhance tensile properties of musculoskeletal grafts; a sorbitol-based PET imaging agent to help diagnose and monitor Enterobacteriaceae infections; genetic variants near estrogen receptor-alpha to predict the risk of breast cancer in Latina women; and more...

Subscribe Now
Free Trial