Separate studies highlight three connections between the microbiome and obesity - a protein, a bacterial species and a gut signature - with therapeutic and prognostic utility.
Frequency Therapeutics is aiming to correct hearing loss by using small molecules to reactivate progenitor cells in vivo.
EMERGING COMPANY PROFILE
Launched this week, SemaThera Inc. has a SEMA3A trap for vascular pathologies of the retina in patients who don't respond to anti-VEGFs.
TRANSLATION IN BRIEF
A pair of studies solidify the seemingly paradoxical hypothesis that blocking type I interferon can help exhausted immune systems battle chronic infections like HIV-1.
Two academic teams exploit bacteria's own iron-scavenging proteins to use against the organisms themselves in therapeutic vaccines.
THE DISTILLERY brings you this week's most essential scientific findings in therapeutics, distilled by Innovations editors from a weekly review of more than 400 papers in 41 of the highest-impact journals in the fields of biotechnology, the life sciences and chemistry. The Distillery goes beyond the abstracts to explain the commercial relevance of featured research, including licensing status and companies working in the field, where applicable.
This week in therapeutics includes important research findings on targets and compounds, grouped first by disease class and then alphabetically by indication.
This week in techniques includes findings about research tools, disease models and manufacturing processes that have the potential to enable or improve all stages of drug discovery and development.