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Taking a BET on hedgehog

By Kai-Jye Lou, Senior Writer

Taking a BET on hedgehog

STANFORD UNIVERSITY SCHOOL OF MEDICI researchers have uncovered an interplay between BET bromodomain proteins and the hedgehog pathway that opens up additional oncology real estate for BET inhibitors.1 The inhibitors could be among the first molecules to work in hedgehog-driven cancers that no longer respond to smoothened inhibitors or other pathway modulators.

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