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In silico prescription

How an in silico model could help prescribe cancer therapies

A new in silico model matches driver mutations with drug mechanisms and shows current guidelines miss a lot of possible treatments.

An in silico model from researchers in Barcelona that matches cancer mutations to drug mechanisms suggests only about 6% of tumors can benefit from approved drugs recommended by clinical guidelines. On the other hand, about 40% of tumors could be treated by drugs marketed for other cancers, while about 73% of tumors could respond to treatments in development.

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Today's Biotech & Pharma News

  • THE DISTILLERY brings you this week's most essential scientific findings in therapeutics, distilled by Innovations editors from a weekly review of more than 400 papers in 41 of the highest-impact journals in the fields of biotechnology, the life sciences and chemistry. The Distillery goes beyond the abstracts to explain the commercial relevance of featured research, including licensing status and companies working in the field, where applicable.

    This week in therapeutics includes important research findings on targets and compounds, grouped first by disease class and then alphabetically by indication.

    This week in techniques includes findings about research tools, disease models and manufacturing processes that have the potential to enable or improve all stages of drug discovery and development.

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