Genentech has pulled back the curtain on its efforts in Parkinson's disease and described a new and potentially disease-modifying target involved in the clearance of damaged mitochondria. The Roche unit now needs to determine whether the deubiquitinase -- USP30 -- is indeed druggable.
Rare pediatric diseases are getting a boost from Alexion Pharmaceuticals, who recently announced a research collaboration with Cincinnati Children's Hospital Medical Center.
TARGETS & MECHANISMS
Researchers at the University of Wisconsin-Madison and Cellectar Biosciences have improved the safety of broad-spectrum cytotoxic drugs by engineering molecules that specifically target malignant cells. The key was exploiting differences in lipid architecture between the two types of cells.
Hedgehog-mediated degradation of chemotherapeutics is a key resistance mechanism in AML, according to findings from Canadian researchers. Their next step is clinical testing of a chemotherapy-hedgehog antagonist combination.
Stabilizing PLA2G5 or inhibiting PLA2G2E to treat obesity; using NOGO-A inhibitors and then physical therapy to improve motor recovery after stroke; antagonizing ABL1 to block neovascularization in retinopathy; and more...
Predicting epidemic variants of mosquito-borne RNA viruses using an in vivo infection system; inducing broadly neutralizing antibodies with an influenza A virus hemagglutinin stem fragment; monitoring miR-1202 expression to predict antidepressant treatment response; and more...