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Tracleer, bosentan

Also known as: Ro 47-0203

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Collapse Summary General Information
Company Actelion Ltd.
DescriptionDual endothelin receptor antagonist
Molecular Target Endothelin A receptor ; Endothelin B receptor
Mechanism of ActionEndothelin A receptor antagonist; Endothelin B receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationHypertension
Indication DetailsTreat advanced primary pulmonary arterial hypertension (PAH); Treat chronic thromboembolic pulmonary hypertension (CTEPH); Treat primary pulmonary hypertension (PPH); Treat pulmonary arterial hypertension (PAH); Treat pulmonary arterial hypertension (PAH) associated with chronic thromboembolic pulmonary hypertension (CTEPH); Treat pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD); Treat pulmonary arterial hypertension (PAH) functional class II; Treat pulmonary arterial hypertension (PAH) functional class II-IV; Treat pulmonary arterial hypertension (PAH) in children; Treat pulmonary hypertension (PH); Treat pulmonary hypertension (PH) secondary to chronic obstructive pulmonary disease (COPD) in HIV patients; Treat pulmonary hypertension (PH) secondary to sickle cell disease (SCD)
Regulatory Designation

Partner

Menarini Group


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