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orteronel (TAK-700)

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Company Takeda Pharmaceutical Co. Ltd.
DescriptionNon-steroidal, selective inhibitor of cytochrome P450 17 alpha-hydroxylase/C17, 20 lyase (CYP17)
Molecular Target Cytochrome P450 17 alpha-hydroxylase/C17, 20 lyase (CYP17)
Mechanism of ActionCytochrome P450 17alpha-hydroxylase/C17,20 lyase (CYP17) inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationProstate cancer
Indication DetailsTreat metastatic castration-resistant prostate cancer (CRPC) in chemotherapy-naïve patients; Treat metastatic castration-resistant prostate cancer (CRPC) that has progressed during or following docetaxel-based therapy; Treat non-metastatic castration-resistant prostate cancer (CRPC)
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