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dibotermin alfa (PF-5208771)

Also known as: InductOs (rhBMP-2/ACS)

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Company Pfizer Inc.
DescriptionRecombinant human bone morphogenic protein 2 (BMP2) with Absorbable Collagen Sponge (ACS) matrix
Molecular Target Bone morphogenetic protein receptor type I (BMPRI) ; Bone morphogenetic protein receptor type II (BMPRII)
Mechanism of ActionBone morphogenic protein (BMP) type I receptor agonist; Bone morphogenic protein (BMP) type II receptor agonist
Therapeutic ModalityBiologic: Protein
Latest Stage of DevelopmentApproved
Standard IndicationBone repair
Indication DetailsTreat acute tibia fractures in adults; Treat fracture repair
Regulatory Designation


Astellas Pharma Inc.

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