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palovarotene (R667) (formerly CLM-001, RG667)

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Company Roche
DescriptionSelective small molecule retinoic acid receptor gamma (RARG) agonist
Molecular Target Retinoic acid receptor gamma (RARG)
Mechanism of ActionRetinoic acid receptor (RAR) agonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II
Standard Indication Musculoskeletal (unspecified)
Indication DetailsTreat fibrodysplasia ossificans progressiva (FOP)
Regulatory Designation U.S. - Fast Track (Treat fibrodysplasia ossificans progressiva (FOP));
U.S. - Orphan Drug (Treat fibrodysplasia ossificans progressiva (FOP));
EU - Orphan Drug (Treat fibrodysplasia ossificans progressiva (FOP))
Partner Clementia Pharmaceuticals Inc.

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