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Regranex, becaplermin

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Company Smith & Nephew plc
DescriptionGel formulation of platelet derived growth factor (PDGF)
Molecular Target Platelet derived growth factor receptor A (PDGFRA) (PDGFR2) (CD140A) ; Platelet derived growth factor receptor B (PDGFRB) (PDGFR1) (CD140B)
Mechanism of ActionPlatelet derived growth factor receptor A (PDGFRA) agonist; Platelet derived growth factor receptor B (PDGFRB) agonist
Therapeutic ModalityBiologic
Latest Stage of DevelopmentMarketed
Standard IndicationDermal ulcers
Indication DetailsTreat diabetic ulcers; Treat lower extremity diabetic neuropathic ulcers; Treat neuropathic diabetic foot ulcers; Treat neuropathic, chronic diabetic foot ulcers; Treat pressure ulcers
Regulatory Designation
Partner

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