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istaroxime (Debio 0614) (formerly PST2744)

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Company Sigma-Tau Group
DescriptionLuso-inotropic agent that inhibits Na+/K+ ATPase pump and activates ATPase Ca++ transporting cardiac muscle slow twitch 2 (ATP2A2; SERCA2A)
Molecular Target Na+/K+ ATPase pump ; ATPase Ca++ transporting cardiac muscle slow twitch 2 (ATP2A2) (SERCA2A)
Mechanism of ActionNa+/K+ ATPase pump inhibitor
Therapeutic Modality 
Latest Stage of DevelopmentPhase II
Standard IndicationHeart failure
Indication DetailsTreat acute decompensated heart failure; Treat acute heart failure (AHF) syndrome
Regulatory Designation
PartnerCVie Therapeutics Ltd.;
Debiopharm Group;
Lee's Pharmaceutical Holdings Ltd.;
ScinoPharm Taiwan Ltd.

 Product Details
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Total Number of DealsTotal Deal ValueTotal Upfront CashTotal Milestone Payments

1

0

0

0


 Deals Details
DateCompanies InvolvedDeal HeadlineTotal Deal ValueTotal Upfront CashTotal Milestone

08/05/2016

Undisclosed

Undisclosed

Undisclosed

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