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Nexavar, sorafenib

Also known as: formerly BAY 43-9006

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Collapse Summary General Information
Company Amgen Inc.
DescriptionInhibitor of CRAF (RAF1) and multiple receptor tyrosine kinases
Molecular Target CRAF (RAF1) ; Vascular endothelial growth factor (VEGF) receptor
Mechanism of ActionRaf inhibitor; FMS-like tyrosine kinase 3 (FLT3) agonist; Platelet derived growth factor receptor (PDGFR) kinase inhibitor; Stem cell factor (SCF) receptor tyrosine kinase (c-Kit) (KIT) (CD117) agonist; Vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) antagonist; Vascular endothelial growth factor (VEGF) receptor 1 (Flt-1) kinase inhibitor
Therapeutic ModalitySmall molecule

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Disease CategoryStandard IndicationIndication DetailsPartnersMilestonesLatest Stage of DevelopmentRegulatory Designation
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