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MK-3682B, MK3

Also known as: MK-3682/MK-8408/MK-5172(grazoprevir)

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Company Merck & Co. Inc.
DescriptionFixed-dose combination of MK-3682, a uridine nucleotide analog HCV NS5B polymerase inhibitor, ruzasvir (MK-8408), an HCV NS5A protein inhibitor, and grazoprevir (MK-5172), an HCV NS3/4A protease inhibitor
Molecular Target HCV NS5B polymerase ; HCV NS5A protein
Mechanism of ActionViral polymerase inhibitor; HCV non-structural protein 5A inhibitor; HCV non-structural protein 5B inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II
Standard IndicationHepatitis C virus (HCV)
Indication DetailsTreat chronic HCV genotype 1, 2 and 3 infection; Treat chronic HCV genotypes 1 and 3 infection
Regulatory Designation

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