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labetuzumab-SN-38 (IMMU-130)

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Company Immunomedics Inc.
DescriptionAntibody against carcinoembryonic antigen (CEA)-related cell adhesion molecule 5 (CEACAM5; CD66e) conjugated with SN-38, the active metabolite of irinotecan
Molecular Target Carcinoembryonic antigen (CEA)-related cell adhesion molecule 5 (CEACAM5) (CD66e)
Mechanism of ActionAntibody-drug conjugate; Binds CEA
Therapeutic ModalityBiologic: Antibody-drug conjugate
Latest Stage of DevelopmentPhase II
Standard IndicationColorectal cancer
Indication DetailsTreat metastatic colorectal cancer in patients who have been previously treated with >=1 prior irinotecan-containing regimen; Treat relapsed or refractory colorectal cancer
Regulatory Designation


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