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Aubagio, teriflunomide

Also known as: HMR1726

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Company Sanofi
DescriptionDihydroorotate dehydrogenase (DHODH) inhibitor
Molecular Target Dihydroorotate dehydrogenase (DHODH)
Mechanism of ActionDihydroorotate dehydrogenase (DHODH) inhibitor; Immune modulation
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationMultiple sclerosis (MS)
Indication DetailsPrevent or delay conversion of clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (MS); Treat relapsing multiple sclerosis (MS); Treat relapsing-remitting multiple sclerosis (RRMS)
Regulatory Designation U.S. - Undisclosed Review (Treat relapsing multiple sclerosis (MS));
EU - Standard Review (Treat relapsing-remitting multiple sclerosis (RRMS));
Canada - Standard Review (Treat relapsing-remitting multiple sclerosis (RRMS))

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