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Oral neratinib (HKI-272, PB272)

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Company Pfizer Inc.
DescriptionOral inhibitor of HER1, HER2 and HER4 kinases
Molecular Target Epidermal growth factor receptor 1 (EGFR1) (HER1) (ErbB1) ; Epidermal growth factor receptor 2 (HER2) (EGFR2) (ErbB2) (neu)
Mechanism of ActionEpidermal growth factor (EGF) receptor 2 (HER2) (ErbB2) (neu) inhibitor; Epidermal growth factor (EGF) receptor 1 (HER1) (ErbB1) inhibitor
Therapeutic ModalitySmall molecule

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