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Tecfidera, dimethyl fumarate (formerly BG-12)

Also known as: BG00012

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Company Biogen Inc.
DescriptionOral dimethyl fumarate that activates the NF-E2-related factor 2 (Nrf2) pathway
Molecular Target Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2)
Mechanism of ActionNuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) activator
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationMultiple sclerosis (MS)
Indication DetailsTreat multiple sclerosis (MS); Treat relapsing-remitting multiple sclerosis (RRMS)
Regulatory Designation U.S. - Fast Track (Treat relapsing-remitting multiple sclerosis (RRMS));
U.S. - Standard Review (Treat multiple sclerosis (MS))
Partner UCB Group

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