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AVP-786, CTP-786 (formerly deuterated dextromethorphan)

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Company Concert Pharmaceuticals Inc.
DescriptionDeuterium-modified dextromethorphan -- an NMDA receptor antagonist, sigma-1 receptor agonist and inhibitor of serotonin and norepinephrine transporters -- plus ultra-low-dose quinidine, a cytochrome P450 2D6 (CYP2D6) inhibitor
Molecular Target NMDA receptor ; Sigma-1 receptor
Mechanism of ActionNMDA receptor agonist; Sigma-1 receptor agonist; Cytochrome P450 2D6 (CYP2D6) inhibitor; Serotonin transporter (SERT) inhibitor; Norepinephrine transporter (NET) inhibitor
Therapeutic ModalitySmall molecule

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