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Oxycodone-naltrexone (ALO-02)

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Company Pfizer Inc.
DescriptionExtended-release oxycodone hydrochloride, an opioid agonist, surrounding sequestered naltrexone hydrochloride, an opioid receptor antagonist
Molecular Target Mu opioid receptor (MOR) (OPRM1)
Mechanism of ActionMu opioid receptor agonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationPain
Indication DetailsTreat moderate to severe chronic low back pain; Treat moderate to severe chronic, non-cancer pain
Regulatory Designation


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