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ALKS 5461

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Company Alkermes plc
DescriptionCombination of ALKS 33, a mu opioid receptor (OPRM1; MOR) antagonist, and buprenorphine
Molecular Target Mu opioid receptor (MOR) (OPRM1) ; Kappa opioid receptor (KOR) (OPRK1)
Mechanism of ActionMu opioid receptor agonist; Kappa opioid receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPivotal
Standard IndicationDepression
Indication DetailsTreat major depressive disorder (MDD); Treat refractory major depressive disorder (MDD)
Regulatory Designation

U.S. - Fast Track (Treat refractory major depressive disorder (MDD))


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