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memantine ER/donepezil (Namzaric) (ADS-8704, MDX-8704)

Also known as: Arimenda

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Company Adamas Pharmaceuticals Inc.
DescriptionOnce-daily, fixed-dose combination of memantine ER, a NMDA receptor antagonist, and donepezil, an acetylcholinesterase (AChE) inhibitor
Molecular Target NMDA receptor ; Acetylcholinesterase (AChE)
Mechanism of ActionAcetylcholinesterase (AChE) inhibitor; NMDA receptor antagonist
Therapeutic ModalitySmall molecule: Combination
Latest Stage of DevelopmentApproved
Standard IndicationAlzheimer's disease (AD)
Indication DetailsTreat moderate to severe Alzheimer's dementia
Regulatory Designation


Actavis plc

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