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Roxadustat (ASP1517, FG-4592)

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Company FibroGen Inc.
DescriptionSmall molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; EGLN)
Molecular Target Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) (EGLN)
Mechanism of ActionHypoxia-inducible factor prolyl hydroxylase inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationAnemia
Indication DetailsTreat anemia in chronic kidney disease (CKD) patients; Treat anemia in chronic kidney disease (CKD) patients not on dialysis and on dialysis; Treat anemia in chronic kidney disease (CKD) patients on dialysis; Treat anemia in patients with end-stage renal disease (ESRD)
Regulatory Designation

Partner

Astellas Pharma Inc.; AstraZeneca plc


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