Therapeutics: μ opioid receptor (MOR; OPRM1); opioid receptor δ 1 (OPRD1, DOR); neurokinin 1 substance P receptor (TACR1)

In vitro and mouse studies identified a peptide-based dual agonist of MOR/DOR and antagonist of TACR1 that could help treat pain. Chemical synthesis and cAMP assays of a series of modified 7-mer pepti...