Therapeutics: CXC chemokine receptor 4 (CXCR4; NPY3R); chemokine CXC motif ligand 12 (CXCL12; SDF-1)

In vitro and mouse studies suggest antagonizing CXCL12-CXCR4 signaling could help treat T cell-ALL (T-ALL). Levels of the CXCL12 receptor CXCR4 were higher on T-ALL cells from patients than on T cells...