Therapeutics: Y-box binding protein 1 (YBX1; YB1); hypoxia-inducible factor 1 α (HIF1A; HIF1-α)

In vitro and mouse studies suggest inhibiting YBX1 could help treat sarcomas that depend on HIF1A for adaptation to low-oxygen environments. In tumor samples from patients with osteosarcoma or Ewing's...