Thursday, July 31, 2014
Publication and contact
Asthma; multiple sclerosis
necrosis factor receptor superfamily member 9 (TNFRSF9; 4-1BB; CD137)
Mouse and in vitro
studies suggest LGALS9 is required for the efficacy of anti-4-1BB antibodies
in inflammatory and autoimmune disease. In a mouse experimental autoimmune
encephalomyelitis (EAE) model of MS and a mouse model of allergic asthma,
anti-4-1BB antibodies caused near-complete suppression of disease development
in wild-type mice but failed to protect Lgals9-deficient mice. In
vitro assays showed that human LGALS9 bound to 4-1BB at a
carbohydrate-recognition domain and that binding is prevented when the site
is deglycosylated. Researchers did not disclose next steps, which could
include identifying LGALS9 agonists.
Pfizer Inc. has the
anti-TNFRSF9 mAb PF-05082566 in Phase I
testing to treat cancer and non-Hodgkin's lymphoma.
Bristol-Myers Squibb Co.
has the TNFRSF9-targeting mAb urelumab (BMS-663513) in Phase I
testing to treat solid tumors.
Published online July 31, 2014
Patent application filed;
available for licensing
Madireddi, S. et al. J.
Exp. Med.; published online June 23, 2014;
Contact: Michael Croft, La Jolla Institute for Allergy &
La Jolla, Calif.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]