Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Musculoskeletal disease

Osteoporosis

Tryptophan hydroxylase 1 (TPH1; TPH)

Rat and in vitro studies identified ursolic acid derivatives that could be useful for treating osteoporosis. In vitro, the lead derivative was shown to bind TPH1 with micromolar affinity. In ovariectomized rats, oral treatment with the compound increased markers of bone formation and improved bone microarchitecture with efficacy comparable to that of injectable parathyroid hormone (PTH). Next steps could include optimizing the lead derivative and evaluating it in additional models of osteoporosis.

SciBX 7(25); doi:10.1038/scibx.2014.744
Published online June 26, 2014

Patent and licensing status unavailable

Fu, H.-J. et al. J. Med. Chem.; published online May 20, 2014;
doi:10.1021/jm5002293
Contact: Xian-Mei Zhou, Nanjing University of Chinese Medicine, Nanjing, China
e-mail:

xianmeizhou@aliyun.com
Contact: Jian-Xin Li, Nanjing University, Nanjing, China
e-mail:

lijxnju@nju.edu.cn